TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
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منابع مشابه
Comment on: Failure of anti-TNF therapy in TNF receptor 1-associated periodic syndrome (TRAPS).
There was no history of ischaemic heart disease, but a routine ECG performed in April 2006 showed first-degree heart block, at a rate of 70 beats/min. Patients having infliximab in our unit are admitted overnight for the first three infusions. The first infusion was uneventful at week 0. Following the second infusion 2 weeks later, she then gave a history of dry cough for 3–4 months. A chest X-...
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A 43-year-old woman with a history of psoriasis vulgaris was admitted for nephrotic syndrome that had started 6 months before. Renal biopsy revealed membranous glomerulonephritis (MGN). She did not receive any therapy for MGN. Two months later she started therapy for psoriasis with adalimumab, which resulted in disappearance of psoriatic skin lesions with progressive reduction of 24h proteinuri...
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TNF-α is a pleiotropic cytokine, which plays a major role in the pathogenesis of numerous autoimmune and/or inflammatory systemic diseases. Systemic vasculitis constitutes a group of rare diseases, characterized by inflammation of the arterial or venous vessel wall, causing stenosis and thrombosis. Treatment of the different type of vasculitis mainly relies on steroids and immunosuppressive dru...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature11307